Calming Seborrheic Serum

4.6
Rated 4.6 out of 5 stars
1,577 Reviews
$49.95
BESTSELLER

“This calming serum completely cleared up my scalp itching and irritation. More than prescribed creams and ointments from my dermatologist!”
— David Walker

Calming Seborrheic Serum

$49.95
4.6
Rated 4.6 out of 5 stars
1,577 Reviews

Soothe your scalp and face. This all-in-one serum helps disrupt the biofilm, clears away signs of fungus, and calms your skin naturally.

  • Reduce flakes

  • Calm Redness

  • Soothe Itching

  • Safe for Malassezia

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  • Reduce flakes

  • Calm Redness

  • Soothe Itching

  • Safe for Malassezia

“This calming serum completely cleared up my scalp itching and irritation. More than prescribed creams and ointments from my dermatologist!”
— David Walker

How It Works

Most skincare products contain ingredients and oils that feed the yeast causing your flaking and redness. This serum works differently.

  1. 1
    Break through the biofilm
    Gets past the protective shield the yeast hides behind, so the formula can actually reach the problem
  2. 2
    Calm the flare-up
    Soothes redness and itching with ingredients that don’t feed the fungus
  3. 3
    Help your skin recover
    Supports your skin barrier so it can heal and stay clear longer
How to use Dermazen products.

Ingredients

Calming Seborrheic Serum


Water, Sodium Chloride (Sea Salt), Xylitol, Methylsulfonylmethane (MSM), Urea, Niacinamide, Colloidal Silver, Sodium Hyaluronate, Aloe Barbadensis Leaf Juice, Citrus Grandis (Grapefruit) Seed Extract, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Rosemary (Rosmarinus Officinalis) Leaf Oil, Limonene*

*natural allergen from essential oils

Dermazen

Ingredient Highlights


Aloe vera

ALOE LEAF JUICE

Aloe barbadensis

Helps soothe irritated scalp and signs of irritation

Xylitol granules

XYLITOL

Xylitol

Works to naturally disrupt the biofilm layer and reduce signs of fungus

Grapefruit with juice

GRAPEFRUIT SEED EXTRACT

Citrus grandis

Helps to calm moody scalps and support healthy hair and skin

Clean, Malassezia-Safe Formulations:

  • Malassezia Safe All of our formulas are made without ingredients that can feed Malassezia (a common yeast that lives on skin and scalp and is associated with flakes, itching, and breakouts). No oils, fatty acids, or esters that this yeast can eat — anywhere in the routine.
  • No Steroids Steroids like hydrocortisone are prescription-style ingredients sometimes used on irritated skin. With long-term use, they’re associated with skin thinning, and stopping them suddenly can lead to rebound flare-ups.
  • No Zinc Pyrithione (ZPT) A common anti-dandruff ingredient found in many medicated shampoos. The European Union banned ZPT in cosmetics in March 2024 over concerns about reproductive safety, though it’s still widely used in U.S. products.
  • No Coal Tar A leftover byproduct from processing coal, used in some old-school medicated shampoos. Has a strong smell, can stain hair and fabric, and has been flagged by health agencies as a possible cancer risk at higher exposure levels.
  • No Selenium Sulfide A medicated ingredient found in some dandruff shampoos. Associated with scalp dryness, irritation, and changes in hair color with regular use.
  • No Sulfates Harsh cleansers (like SLS and SLES — the bubbly stuff in many shampoos and body washes). Can strip away natural oils and leave sensitive scalps and skin feeling tight and dry.
  • No Parabens A group of preservatives used in tons of personal care products to keep them from spoiling. Studied for acting like estrogen in the body and have been detected in human tissue samples.
  • No Phthalates A group of chemicals often hidden inside “fragrance” blends and used to soften plastics. Studied for their effects on hormones and reproductive health.
  • No Silicones Synthetic ingredients (look for “-cone” or “-siloxane” on labels) that coat hair to give it temporary slip and shine. Build up over time and can trap dirt and oil against the scalp.
  • No PEGs Petroleum-based ingredients (made from the same source as gasoline) used to mix oil and water in many products. Often contaminated during manufacturing with 1,4-dioxane, a chemical of concern flagged by the EPA.
  • No Synthetic Fragrance The words “fragrance” or “parfum” on a label can hide dozens of undisclosed chemicals. Among the most commonly reported sources of skin sensitivity in personal care products.
  • No Mineral Oil A leftover byproduct from making gasoline, used in many lotions, balms, and hair products. Forms an occlusive layer on skin that can trap dirt against pores.
  • No Artificial Dyes Synthetic colorings (the FD&C and D&C numbers you see on labels) added just to make products look pretty. Made from petroleum and associated with skin sensitivity reactions in some people.
  • No Talc A soft mineral powder used in some body powders and makeup. Has been the subject of major lawsuits over contamination with asbestos, a regulated mineral fiber classified as a known carcinogen by international health agencies.
  • No Triclosan An antibacterial chemical once added to soaps and personal care products everywhere. The FDA banned it from over-the-counter washes in 2016 because companies couldn’t prove it was safe or worked any better than plain soap.
  • No BHA/BHT Synthetic preservatives used to keep oils in lotions, lip balms, and cosmetics from going rancid. Studied for their effects on hormones and flagged by some health agencies as ingredients of concern.
  • No DEA/TEA Two foam-boosting and pH-balancing chemicals (diethanolamine and triethanolamine) used in many shampoos and cleansers. Can react with other ingredients in the bottle to form nitrosamines — a group of chemicals flagged as a safety concern.
  • No EDTA A chemical added to many products to grab onto minerals in tap water and keep formulas stable. Doesn’t break down well in nature and builds up in lakes, rivers, and oceans after it rinses down the drain.

How to Use

  1. Apply the serum and massage it into your scalp and face thoroughly the night before (or at least two hours before) you plan to wash your hair - even if that is every week or two.
  2. The serum can also be rinsed out with water (without shampoo) either with a full rinse or with a wet washcloth in between braids across the scalp.
  3. Some folks with textured hair use the serum as a leave-in product, since the holistic ingredients will naturally absorb into the scalp for lasting relief.
  1. Apply a generous amount of serum to your moody skin or scalp before bed, making sure to cover all of the affected area.
  2. Massage in the formula as you thank your body for all its gifts.
  3. In the morning*, rinse your hair with water or wash with a malassezia-safe shampoo before styling. If applied to the face, the soothing ingredients will absorb overnight.
  4. Enjoy all-day peaceful skin and peace of mind.

*If you prefer to shower at night, just be sure to allow the serum to absorb into your scalp for at least two hours before rinsing or washing.

For Best Results

To further calm your scalp and prevent flakes and irritation, wash with the Scalp Therapy Shampoo.

For your face, first wash with the Purifying Facial Cleanser before applying the serum, then protect your skin's peace with the Soothing Malassezia Moisturizer after the serum.

Stinging Is Possible & Natural

If your skin is highly inflamed, you might experience a stinging sensation, mostly from the sea salt and tea tree essential oil. This is normal.

The aloe and other soothing ingredients will usually calm any discomfort within a minute or two. And as your skin barrier becomes healthier over time, the stinging will become less intense or disappear completely.

If your skin is extra sensitive and the stinging feels unbearable, you can dilute the serum by 50% with purified water and apply it to your skin. The serum is our strongest formula, so there are many folks in the Dermazen community who have seen great results with a diluted serum.

Shipping & Returns

Your order ships fast: we send packages out from Oceanside, CA within 24 business hours (Mon–Sat), with tracking emailed automatically. Standard U.S. delivery is typically 2–5 business days (USPS), and FedEx 2-Day is available if you need it sooner.

Not sure it’s right for your skin? Every U.S. order is backed by our 60-Day Peaceful Skin Guarantee (starting on the day your package is marked delivered). If your skin hasn’t improved, you can return your products for a full refund.

Steroid-Free icon Steroid-Free
Paraben & Sulfate Free icon Paraben & Sulfate Free
Synthetic Fragrance Free icon Synthetic Fragrance Free
Color Safe icon Color Safe
Gentle & Non-Toxic icon Gentle & Non-Toxic
Vegan icon Vegan

The Key to Calming Your Dandruff & Seborrheic Dermatitis

Why Moisturizing Will Never Be Enough

Life Changing Results

Customer Testimonials

Photo of Brent H., verified customer.

The only product that has worked. I got the peaceful skin system bundle after a recent flare up. My skin has made incredible improvements. I’m so grateful I found something that actually works for me.”

- Brent H. Verified check star Verified Customer
Photo of Camille G., verified customer.

My skin is clearer than it’s ever been. I am shocked at how well this has worked to clear up the totally entrenched flaking and acne I had across my nose for years. Really nice smelling and feeling.”

- Camille G. Verified check star Verified Customer
Photo of Raquel T., verified customer.

As close to a miracle as you can get. After years of trying everything to fix my itchy, flaky skin on my face, scalp, and around my nose, these products solved it within days.”

- Raquel T. Verified check star Verified Customer
Calming Seborrheic Serum product

Why
Dermazen?

We started Dermazen because we lived the struggle personally: flakes, redness, embarrassment, and products that helped for a week…then stopped working.

So we went deep into the research and took a different approach: formulas that outsmart the yeast, simple routines anyone can follow, and holistic ingredients to calm our skin (without feeding future flare-ups).

Frequently Bought With


Customer Reviews


4.6
Rated 4.6 out of 5 stars
Based on 1,577 reviews
Total 5 star reviews: 1.2k Total 4 star reviews: 196 Total 3 star reviews: 76 Total 2 star reviews: 36 Total 1 star reviews: 56
89%would recommend this product
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1,577 reviews
  • LC
    Lynn C.
    Verified Buyer
    I recommend this product
    Where did you need relief? Face, Scalp
    What did this product help with? Flakes, Itching
    How old are you? 45-54
    What is your gender? Female
    What texture is your hair? Wavy
    Rated 5 out of 5 stars
    23 hours ago
    Finally found relief from itchiness & flakes!

    I'm so excited to have discovered derma zen's serum & shampoo. I've had itchy flaky scalp & eyebrows for many years & have tried many products. Derma zen's products were the 1st to actually work! I'll be a lifetime customer. Thank you derma zen team for creating such valuable products!

  • SB
    Shameka B.
    Verified Buyer
    I recommend this product
    Where did you need relief? Face
    What did this product help with? Itching
    How old are you? 45-54
    What is your gender? Female
    What texture is your hair? Textured
    Rated 4 out of 5 stars
    1 week ago
    Good stuff

    I tried it about 6 months ago and I literally have calmer skin. Thank *** I stumbled upon this product. Not only did it help with the itching on my face also with the itching in my hair.

  • DH
    D. H.
    Verified Buyer
    I recommend this product
    Where did you need relief? Scalp
    What did this product help with? Flakes, Itching, Build-Up
    How old are you? 35-44
    What texture is your hair? Curly
    Rated 5 out of 5 stars
    1 week ago
    Works wonders!

    It got rid of all the flakes and itching!! You just have to be consistent!! It's definitely worth it!

  • SF
    Sarah F.
    Verified Buyer
    I recommend this product
    Where did you need relief? Scalp
    What did this product help with? Flakes, Itching, Skin Health, Build-Up
    How old are you? 25-34
    What is your gender? Female
    What texture is your hair? Wavy
    Rated 5 out of 5 stars
    3 weeks ago
    BEST seb derm prevention EVER

    Incredible product! It saves my hair from flares that lead to dermatitis every time! I have an autoimmune condition, and this is the best product I've found out there, period. Free from harsh synthetic fragrances and everything. SO glad this exists.

  • ES
    Emma S.
    Verified Buyer
    I recommend this product
    Where did you need relief? Scalp, Ears, Face
    What did this product help with? Flakes, Itching, Skin Health, Build-Up
    How old are you? 35-44
    What is your gender? Female
    What texture is your hair? Wavy
    Rated 5 out of 5 stars
    3 weeks ago
    Saved my scalp from doom

    When I experienced the worst scalp seborrheic dermatitis flareup in my life, this was the product that really turned the tide and not only gave me immediate itch relief, but also finally seemed to break through and make real progress towards complete recovery. I still use it now when I have mild flare ups and it helps nip them in the bud early. Highly recommend to any SD sufferers and I am extremely grateful to Dermazen for saving my scalp from utter devastation!