Ingredients How It Works Shipping & Returns Testimonials How to Use
Ingredients How It Works Shipping & Returns Testimonials How to Use

“using the shampoo and serum on my scalp for 4 months and can’t remember the last time I needed to scratch an itch!”
— Nicole Arredondo

Leave-in Scalp Serum

$39.96
4.6
Rated 4.6 out of 5 stars
1,580 Reviews

Leave-in Scalp Serum

4.6
Rated 4.6 out of 5 stars
1,580 Reviews
$39.96

Clear flakes and itching without nuking your scalp and stripping your hair. Our leave-in serum works 24/7, feeding your scalp and starving out the root cause of flakes day and night.

  • Prevent Flakes

  • Improve Hair Health

  • Overnight Relief

  • Calm Itching

60-Day Money Back Guarantee

  • Prevent Flakes

  • Improve Hair Health

  • Overnight Relief

  • Calm Itching

“using the shampoo and serum on my scalp for 4 months and can’t remember the last time I needed to scratch an itch!”
— Nicole Arredondo

How It Works

Most dandruff shampoos only address symptoms on the surface. This system targets the root cause — the yeast living beneath your flakes — so relief actually lasts.

  1. 1
    Disrupt the yeast’s hiding spot
    The serum penetrates the biofilm shield that protects the fungus and keeps other products from working
  2. 2
    Cleanse without feeding the problem
    Our shampoo removes buildup and flakes without the oils and sulfates that trigger new flare-ups
Man looking in a mirror while examining his scalp.

Ingredients

Calming Seborrheic Serum


Water, Sodium Chloride (Sea Salt), Xylitol, Methylsulfonylmethane (MSM), Urea, Niacinamide, Colloidal Silver, Sodium Hyaluronate, Aloe Barbadensis Leaf Juice, Citrus Grandis (Grapefruit) Seed Extract, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Rosemary (Rosmarinus Officinalis) Leaf Oil, Limonene*

*natural allergen from essential oils

Dermazen

Ingredient Highlights


Aloe vera

ALOE LEAF JUICE

Aloe barbadensis

Helps soothe and calm signs of visible irritation and moody scalp

Urea granules

UREA

Urea

Boosts hydration and supports a calm, balanced scalp

Grapefruit with juice

GRAPEFRUIT SEED EXTRACT

Citrus grandis

Helps to support a calm, clear, balanced scalp

Clean, Malassezia-Safe Formulations:

  • Malassezia Safe All of our formulas are made without ingredients that can feed Malassezia (a common yeast that lives on skin and scalp and is associated with flakes, itching, and breakouts). No oils, fatty acids, or esters that this yeast can eat — anywhere in the routine.
  • No Steroids Steroids like hydrocortisone are prescription-style ingredients sometimes used on irritated skin. With long-term use, they’re associated with skin thinning, and stopping them suddenly can lead to rebound flare-ups.
  • No Zinc Pyrithione (ZPT) A common anti-dandruff ingredient found in many medicated shampoos. The European Union banned ZPT in cosmetics in March 2024 over concerns about reproductive safety, though it’s still widely used in U.S. products.
  • No Coal Tar A leftover byproduct from processing coal, used in some old-school medicated shampoos. Has a strong smell, can stain hair and fabric, and has been flagged by health agencies as a possible cancer risk at higher exposure levels.
  • No Selenium Sulfide A medicated ingredient found in some dandruff shampoos. Associated with scalp dryness, irritation, and changes in hair color with regular use.
  • No Sulfates Harsh cleansers (like SLS and SLES — the bubbly stuff in many shampoos and body washes). Can strip away natural oils and leave sensitive scalps and skin feeling tight and dry.
  • No Parabens A group of preservatives used in tons of personal care products to keep them from spoiling. Studied for acting like estrogen in the body and have been detected in human tissue samples.
  • No Phthalates A group of chemicals often hidden inside “fragrance” blends and used to soften plastics. Studied for their effects on hormones and reproductive health.
  • No Silicones Synthetic ingredients (look for “-cone” or “-siloxane” on labels) that coat hair to give it temporary slip and shine. Build up over time and can trap dirt and oil against the scalp.
  • No PEGs Petroleum-based ingredients (made from the same source as gasoline) used to mix oil and water in many products. Often contaminated during manufacturing with 1,4-dioxane, a chemical of concern flagged by the EPA.
  • No Synthetic Fragrance The words “fragrance” or “parfum” on a label can hide dozens of undisclosed chemicals. Among the most commonly reported sources of skin sensitivity in personal care products.
  • No Mineral Oil A leftover byproduct from making gasoline, used in many lotions, balms, and hair products. Forms an occlusive layer on skin that can trap dirt against pores.
  • No Artificial Dyes Synthetic colorings (the FD&C and D&C numbers you see on labels) added just to make products look pretty. Made from petroleum and associated with skin sensitivity reactions in some people.
  • No Talc A soft mineral powder used in some body powders and makeup. Has been the subject of major lawsuits over contamination with asbestos, a regulated mineral fiber classified as a known carcinogen by international health agencies.
  • No Triclosan An antibacterial chemical once added to soaps and personal care products everywhere. The FDA banned it from over-the-counter washes in 2016 because companies couldn’t prove it was safe or worked any better than plain soap.
  • No BHA/BHT Synthetic preservatives used to keep oils in lotions, lip balms, and cosmetics from going rancid. Studied for their effects on hormones and flagged by some health agencies as ingredients of concern.
  • No DEA/TEA Two foam-boosting and pH-balancing chemicals (diethanolamine and triethanolamine) used in many shampoos and cleansers. Can react with other ingredients in the bottle to form nitrosamines — a group of chemicals flagged as a safety concern.
  • No EDTA A chemical added to many products to grab onto minerals in tap water and keep formulas stable. Doesn’t break down well in nature and builds up in lakes, rivers, and oceans after it rinses down the drain.

How to Use

  1. Apply the serum and massage it into your scalp and face thoroughly the night before (or at least two hours before) you plan to wash your hair - even if that is every week or two.
  2. The serum can also be rinsed out with water (without shampoo) either with a full rinse or with a wet washcloth in between braids across the scalp.
  3. Some folks with textured hair use the serum as a leave-in product, since the holistic ingredients will naturally absorb into the scalp for lasting relief.
  1. Apply a generous amount of serum to your moody skin or scalp before bed, making sure to cover all of the affected area.
  2. Massage in the formula as you thank your body for all its gifts.
  3. In the morning*, rinse your hair with water or wash with a malassezia-safe shampoo before styling. If applied to the face, the soothing ingredients will absorb overnight.
  4. Enjoy all-day peaceful skin and peace of mind.

*If you prefer to shower at night, just be sure to allow the serum to absorb into your scalp for at least two hours before rinsing or washing.

For Best Results

To further calm your scalp and prevent flakes and irritation, wash with the Scalp Therapy Shampoo.

For your face, first wash with the Purifying Facial Cleanser before applying the serum, then protect your skin's peace with the Soothing Malassezia Moisturizer after the serum.

Stinging Is Possible & Natural

If your skin is highly inflamed, you might experience a stinging sensation, mostly from the sea salt and tea tree essential oil. This is normal.

The aloe and other soothing ingredients will usually calm any discomfort within a minute or two. And as your skin barrier becomes healthier over time, the stinging will become less intense or disappear completely.

If your skin is extra sensitive and the stinging feels unbearable, you can dilute the serum by 50% with purified water and apply it to your skin. The serum is our strongest formula, so there are many folks in the Dermazen community who have seen great results with a diluted serum.

Shipping & Returns

Your order ships fast: we send packages out from Oceanside, CA within 24 business hours (Mon–Sat), with tracking emailed automatically. Standard U.S. delivery is typically 2–5 business days (USPS), and FedEx 2-Day is available if you need it sooner.

Not sure it’s right for your skin? Every U.S. order is backed by our 60-Day Peaceful Skin Guarantee (starting on the day your package is marked delivered). If your skin hasn’t improved, you can return your products for a full refund.

Steroid-Free icon Steroid-Free
Paraben & Sulfate Free icon Paraben & Sulfate Free
Synthetic Fragrance Free icon Synthetic Fragrance Free
Color Safe icon Color Safe
Gentle & Non-Toxic icon Gentle & Non-Toxic
Vegan icon Vegan

Customer Testimonials

Photo of Brent H., verified customer.

The only product that has worked. After a recent flare up I tried this serum and my scalp has made incredible improvements. I’m so grateful I found something that actually works for me.”

- Brent H. Verified check star Verified Customer
Photo of Camille G., verified customer.

My scalp is clearer than it’s ever been. I am shocked at how well this has worked to clear up the totally entrenched flaking and itching I had for years. Really nice smelling and feeling.”

- Camille G. Verified check star Verified Customer
Photo of Raquel T., verified customer.

As close to a miracle as you can get. After years of trying everything to fix my itchy, flaky scalp, these products solved it within days.”

- Raquel T. Verified check star Verified Customer
Calming Seborrheic Serum product

Why
Dermazen?

We started Dermazen because we lived the struggle personally: visible flakes, redness, blemishes, embarrassment, and products that helped for a week…then stopped working.

So we spent years learning about ingredients and formulations, and took a different approach: formulas made without ingredients known to feed Malassezia, so skin can feel more balanced and comfortable.

4.6
Rated 4.6 out of 5 stars
Based on 1,580 reviews
Total 5 star reviews: 1.2k Total 4 star reviews: 196 Total 3 star reviews: 76 Total 2 star reviews: 36 Total 1 star reviews: 56
89%would recommend this product
Slide 1 selected
1,580 reviews
  • CD
    Claretta D.
    Verified Buyer
    I recommend this product
    Where did you need relief? Scalp
    What did this product help with? Build-Up, Itching, Flakes, Skin Health
    How old are you? 35-44
    What is your gender? Female
    What texture is your hair? Textured
    Rated 5 out of 5 stars
    10 hours ago
    Best Part of the package

    My only complaints are the size of the bottle for the price. For me, this is what makes this skin system different than all the others I have tried. You can feel it working. It is gentle and makes the shampoo work more efficiently. However, I run out before I run out if shampoo and that sucks because I do not want to buy a whole bundle for the serum alone is $50 so usually I buy the bundle. My locs are long and this helps prevent the build up in my scalp from getting stuck in my locs. I wish I had this 11 years ago when my loc journey began.

  • AG
    Annette G.
    Verified Buyer
    I recommend this product
    Where did you need relief? Scalp, Ears, Face
    What did this product help with? Build-Up, Itching, Flakes
    How old are you? 35-44
    What is your gender? Female
    What texture is your hair? Wavy
    Rated 5 out of 5 stars
    6 days ago
    Wish I would have found this sooner

    It may seem a little pricey. But it works. And it’s brought me so much relief not only by helping get rid flakes and itchiness but also I can wear my black shirts and dresses again!

  • DS
    Debra S.
    Verified Buyer
    I recommend this product
    Where did you need relief? Scalp, Face
    What did this product help with? Itching, Build-Up, Skin Health
    How old are you? Over 65
    What is your gender? Female
    What texture is your hair? Straight
    Rated 5 out of 5 stars
    6 days ago
    i finally feel progress

    i have seborrheic dermatitis due to Parkinson's and i feel your approach has helped calm my itch and although i still have quite a thick buildup, i feel hopeful that i will win out. The medicated shampoo prescribed by my dermatologist was fighting a losing battle. He told me to use it on my face as well, which did nothing, the serum has been working to thin out the buildup on my forehead.

  • LC
    Lynn C.
    Verified Buyer
    I recommend this product
    Where did you need relief? Face, Scalp
    What did this product help with? Flakes, Itching
    How old are you? 45-54
    What is your gender? Female
    What texture is your hair? Wavy
    Rated 5 out of 5 stars
    2 weeks ago
    Finally found relief from itchiness & flakes!

    I'm so excited to have discovered derma zen's serum & shampoo. I've had itchy flaky scalp & eyebrows for many years & have tried many products. Derma zen's products were the 1st to actually work! I'll be a lifetime customer. Thank you derma zen team for creating such valuable products!

  • SB
    Shameka B.
    Verified Buyer
    I recommend this product
    Where did you need relief? Face
    What did this product help with? Itching
    How old are you? 45-54
    What is your gender? Female
    What texture is your hair? Textured
    Rated 4 out of 5 stars
    4 weeks ago
    Good stuff

    I tried it about 6 months ago and I literally have calmer skin. Thank *** I stumbled upon this product. Not only did it help with the itching on my face also with the itching in my hair.

Life Changing Results

Leave-in Scalp Serum

$39.96

60-Day Money Back Guarantee

Free shipping on 8 oz bottle orders. 60-Day Money Back Guarantee on all orders.