🩺 Dermatologist Tested (HRIPT safety-tested)
🔬 Clinically Studied*
⭐ 1,592+ Reviews · 94% Would Recommend
Made in the USA
🩺 Dermatologist Tested (HRIPT safety-tested)
🔬 Clinically Studied*
⭐ 1,592+ Reviews · 94% Would Recommend
Made in the USA
🩺 Dermatologist Tested (HRIPT safety-tested)
🔬 Clinically Studied*
⭐ 1,592+ Reviews · 94% Would Recommend
Made in the USA
Shop
Ingredients
Reviews
Our Story
Shop
Ingredients
Reviews
Our Story
4.57/5 · 1,592+ Reviews · 94% Would Recommend
An overnight serum for flaky, irritated skin. Apply it before bed and leave it on for 8+ hours. Wake up to calmer skin, with your skin barrier supported instead of stripped.
Fewer flakes
Less itching, less redness
Calmer skin by morning
Supports your skin barrier instead of stripping it
Pay in 2 interest-free installments of $19.99 with
60-Days or its Free · Dermatologist Tested
📦 Free shipping on US orders over $75
"After YEARS of trying everything from soaps to lotions to creams and steroids, I finally found something that really works. Within two days, the itching and flakes were gone! I highly recommend this to anyone that has suffered and tried everything they could find."
-John
Why It's Different
8+ Hours vs. 2 Minutes
Rinse-off shampoos and medicated washes get about two minutes of contact before they go down the drain. This serum stays on 8+ hours overnight, while your skin actually rests.
Supports Your Barrier Instead of Stripping It
The harsh surfactants in many dandruff shampoos can strip the scalp's protective barrier over time, which can leave skin feeling drier, tighter, and more reactive with each wash. This serum is formulated without those surfactants, to support your barrier instead.
Clears the Buildup Layer Most Treatments Miss
Oil, dead skin, and old product residue can build up at the skin's surface over time. Most treatments don't remove the layer of oil, dead skin, and old product residue that can keep your scalp flaking. This serum is formulated to help clear that layer while it works overnight.
No Oils That Can Work Against You
Many popular oils, like coconut, argan, and olive, contain a fatty acid that research links to scalp barrier disruption and can interfere with your skin's natural shedding process. This serum is formulated without them.
How To Use
The Routine
An overnight, leave-on formula for flaky, itchy, reactive skin, formulated to support the skin barrier instead of stripping it.
APPLY
1. Apply to clean, dry or towel-dried skin (scalp, hairline, or wherever you need it) before bed.
Leave on
2. Leave it on overnight for 8+ hours while it works.
Rinse (Or Skip)
3. Rinse out with your normal wash, or leave it in through your next wash day if you go longer between washes.
Frequency
Use nightly. This serum is formulated to be gentle enough for daily use.
How Long Does Relief Take?
Every scalp is different, and results vary, but here's a general sense of what to expect.
Day 1
"I have only used the serum once and it's already helped immensely! I put it on and wore it overnight until I washed my hair the next day... my scalp is calm, doesn't feel 'hot,' and isn't itching or irritated at all."
— Chanel Blinn · ★★★★★
Week 1
In a 4-week clinical study, there was a significant improvement in the appearance of flakiness, redness, and scale buildup after just 1 week.*
"I've been battling with this issue for 20+ years! ... I honestly used this product for less than a week, and it cleared up fully. I am so so so happy I found this stuff. Life changing!"
— Kevin W. · ★★★★★
Weeks 2–3
"It took about 3-4 days of using it twice a day for the itching and irritation to finally calm down for real. It has been three weeks since I started, and my scalp has been so consistently calm that I even forgot to apply it for 2-3 days."
— Delia L. · ★★★★★
Week 4+
92% of clinical trial participants reported fewer flakes and reduced buildup, and their scalp feeling calmer and more soothed, after 4 weeks.*
Built By Someone Who Lived It, Not A Boardroom
Our co-founder spent more than a decade cycling through prescriptions, steroid creams, and natural remedies for his own flaky, irritated skin, watching each one work for a little while and then stop. Every option either stripped his skin or left the buildup underneath untouched.
So he formulated something different: a nightly serum built to support the skin barrier while helping clear away the buildup layer other products leave behind. That formula became the Calming Seborrheic Serum.
More From Real Customers
"I've never had such settled scalp. I wash my hair every 6-7 days (I have natural African American hair, which usually gets washed every 2 weeks). This last week I was so tired from work travel and was able to extend wash day another week."
Kanishia Wallace
"I didn't need to wash my hair in 2 days due to flaky scalp. I went a whole two weeks without a wash. I have natural wavy 4c hair."
Daphyane Ayala
"I've been using this product for 1 year now and it's been life changing... this serum is a bargain. The formula is perfect, don't change anything!"
PC
"Decades of trying new and different products, getting excited when they calm my skin for a couple weeks and then feeling disappointed when it stops working. Surprisingly, this serum has been absolutely incredible... I started a subscription because so far I love this product!"
Emily Haber
How It Stacks Up
Swipe to compare
Calming Seborrheic Serum
Medicated Shampoos & Prescriptions
Natural Oils & Home Remedies
Contact time
8+ hours (overnight serum)
~2 minutes, rinse-off
Varies, often left on
Skin barrier
Formulated to support it
Can strip it with repeated use
Can disrupt it (oleic acid)
The buildup layer
Clears it overnight
Not typically designed to reach it
Can make it worse
What's left out
No harsh sulfates, no heavy oils or waxes
Often contains sulfates, dyes, fragrances
Often contains oleic-acid-rich oils
Real guarantee
60-Day Peaceful Skin Guarantee
Rarely offered
None
Swipe to compare
Clinically Studied.
In a 4-week clinical study, participants using the Calming Seborrheic Serum reported:
92%
Reduction in Flakiness*
92%
reduction in scalp buildup*
92%
said their scalp felt calmer and more soothed*
88%
reported improved overall scalp health*
76%
felt less self-conscious about their scalp*
Dermatologist-confirmed, based on evaluation of before-and-after photos:
77%
showed dermatologist-confirmed improvement in scalp health*
66%
showed dermatologist-confirmed improvement in flakiness*
Questions, Answered
I've already tried prescriptions and medicated shampoos. How is this different?
Most prescriptions and medicated shampoos are designed to rinse off in about two minutes, and many can strip the skin's protective barrier with repeated use. This serum stays on for 8+ hours overnight and is formulated to support the barrier instead of stripping it, while targeting the buildup layer most rinse-off treatments were never designed to reach.
Can I use this alongside a prescription treatment or steroid cream from my dermatologist?
We always recommend checking with your dermatologist before combining treatments. This serum is formulated without the harsh surfactants common in medicated shampoos, but your dermatologist knows your specific treatment plan best.
I've already tried natural oils and home remedies. Won't this be the same?
Not exactly. Many popular oils, like coconut, argan, and olive, contain a fatty acid that research links to disrupting the skin barrier and interfering with your skin's natural shedding process, which can contribute to more buildup, not less. This serum is formulated without those oils.
How fast will I notice a difference?
In a 4-week clinical study, participants reported noticeable improvement as early as week one, with 92% reporting less flaking and buildup by week four.* Individual results vary, and consistency matters most.
What if it doesn't work for me?
You're covered by our 60-Day Peaceful Skin Guarantee. Try it for up to 60 days. If your skin isn't noticeably calmer, we'll give you a full refund.
60 Days Or It's Free.
Fewer Flakes. Calmer Scalp. Zero Guesswork.
Try the Complete System for 60 days. If your scalp isn't calmer, it's on us.
- PPPaula P.Verified BuyerRated 5 out of 5 stars1 week agoGreat Product
I only needed to use this product a few times to see dramatic results. In a few weeks, it did what prescription products couldn't do in years.
- HBHarold B.Verified BuyerRated 5 out of 5 stars2 weeks agoWent too long trying other products… but only THIS gets it done for me.👍🏿
If you’ve got scalp irritation… DONT think about it, DONT wait, just BUY IT!! 🙌🏿
You’ll thank yourself later… Just remember, consistency is key. (Do the subscription)🙏🏿
- NKNiharika K.Verified BuyerRated 4 out of 5 stars2 weeks agoLove this product
This was my introduction to Dermazen. This product helped immensely when I first got it and continues to be excellent. I alternate with this serum and the moisturizer
- BDBrooke D.Verified BuyerRated 5 out of 5 stars2 weeks agoInstant soothing
Partnered with the smampoo this stuff is amazing. I put in on right before bed and it instantly soothes my scalp making sleep so much more pleasant. I tried many products before Dermazen with no success. It has been a life saver
- CWCatreena W.Verified BuyerRated 5 out of 5 stars2 weeks agoI use this EVERYWHERE
I put it on my scalp a few times a week and sometimes in combination with the scalp moisturizer. The absolute beauty of this one, I put it anywhere I see a dry patch. It clears it right up, sometime overnight and other times a couple of applications. It works miracles. I really wish I had taken before/after pictures of the area under my *******. It was really dry but now it's not. Makes me happy!
In a 4-week open-label, single-group clinical consumer perception study conducted by Citruslabs (n=27 test subjects, 18 and over). Results based on participant self-report unless noted as dermatologist-confirmed, based on dermatologist evaluation of before-and-after scalp photos. Individual results may vary.
*Try Calming Seborrheic Serum for up to 60 days. If your skin isn't noticeably calmer, we'll give you a full refund.