🚫 No Harsh Sulfates
⏱️ 60 Days or It's Free*
🌙 Overnight Formula
🚚 Free US Shipping
🚫 No Harsh Sulfates
⏱️ 60 Days or It's Free*
🌙 Overnight Formula
🚚 Free US Shipping
🚫 No Harsh Sulfates
⏱️ 60 Days or It's Free*
🌙 Overnight Formula
🚚 Free US Shipping
4.5 · 274 Verified Reviews · 88% would recommend
The Complete System: Buy 2 Serums, Get a Free Shampoo, Conditioner & Scalp Scrubber
A 4-step overnight system for flaky, itchy, reactive scalps — supports the skin barrier instead of stripping it, without the harsh sulfates that can make flaking worse.
No Harsh Sulfates
60 Days or It's Free*
Overnight Formula
Free US Shipping
2,000 sold in the last 30 days
Just The Serum — 1 Bottle
Prefer to start smaller? Try one bottle first.
Calming Seborrheic Serum (4oz)
One-time purchase or subscribe & save
$49.95
$49.95
Add to Cart —
$49.95
60-Day Supply
The Complete System — 3 Free Gifts
Here's everything in your system, and what it's worth:
Calming Seborrheic Serum
8oz
x 2
60 day supply
$159.90
$159.90
Scalp Therapy Shampoo
8oz
$49.99
FREE
Nourishing Conditioner
8oz
$44.95
FREE
Reusable
$19.95
FREE
2 Serums + Free Shampoo, Conditioner & Scrubber, was $274.79 now $159.90 Best Value + 3 Free Gifts, Get the Complete System.
GET THE COMPLETE SYSTEM —
$274.79
$159.90
60 DAYS OR IT'S FREe*
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Dermatologist Tested (HRIPT safety-tested)
Clinically Studied
4,206+ Reviews · 91% Would Recommend
Made in the USA
Skin Barrier-Supporting Formula
Dermatologist Tested (HRIPT safety-tested)
Clinically Studied
4,206+ Reviews · 91% Would Recommend
Made in the USA
Skin Barrier-Supporting Formula
Dermatologist Tested (HRIPT safety-tested)
Clinically Studied
4,206+ Reviews · 91% Would Recommend
Made in the USA
Skin Barrier-Supporting Formula
"I struggled with 'dry flakes' my whole life, they would come off in HUGE chunks, leaving my scalp red and inflamed. I use to have to go to the dermatologist and get expensive prescriptions for this problem until I found dermazen! Literally after 2 days of using it my scalp was already noticeably healthier. I have kinky-curly 4B hair and wash my hair twice a week, this product has allowed me to go that long without any flakes! I've been using for over 2 years and I will never not have this in my home!"
-Maya F.
Why It's Different
8+ Hours vs. 2 Minutes
Prescriptions and dandruff shampoos can rinse off in two minutes. Our serum stays on 8+ hours overnight.
Supports Your Barrier Instead Of Stripping It
Harsh surfactants in medicated shampoos can strip your scalp's barrier. Ours is formulated without them.
Clears The Buildup Layer Most Treatments Miss
Most treatments don't remove the layer of oil, dead skin, and old product residue that can keep your scalp flaking.
A System, Not A Single Prescription
One cream can't cover wash day, overnight, and in between. This system does, product by product.
The Wrong Shampoo Can Keep You Flaking
Most serum-only customers are still washing with sulfates that can cause irritation. The shampoo and conditioner in this system replace those products, helping your scalp actually get the relief it needs.
Targets the Cycle, Not Just the Flakes
Many oils and creams contain a fatty acid that can disrupt your scalp's barrier and keep it stuck in the flake cycle. Ours is formulated without that fatty acid, so your scalp isn't starting over between treatments.
How To Use
The Routine
A 4-step overnight system for flaky, itchy, reactive scalps. Supports the skin barrier instead of stripping it, without the harsh sulfates that can make flaking worse.
overnight
1. Apply the Calming Seborrheic Serum before bed
for 8+ hours of contact time while you sleep.
Wash day
2. Cleanse with the Scalp Therapy Shampoo
and gently massage with the Scalp Scrubber to lift buildup without stripping the barrier.
Wash day
3. Follow with the Nourishing Conditioner
to strengthen and soften your hair without the barrier-disrupting lipids in most conditioners.
Frequency
Once daily is the standard protocol. If you wash less frequently, use the serum overnight as a leave-on in between wash days.
How Long Does Relief Take?
Every scalp is different, and results vary, but here's a general sense of what the routine can look like over 60 days.
Days 1–3
"I have only used the serum once and it's already helped immensely! I put it on and wore it overnight until I washed my hair the next day... my scalp is calm, doesn't feel 'hot,' and isn't itching or irritated at all."
— Chanel Blinn, Verified Buyer · ★★★★★
Days 4–10
In our 4-week clinical study, there was a significant improvement in the appearance of flakiness, redness, and scale buildup after just 1 week.*
Days 11–21
"The thick scales on my scalp were gone in three weeks! I wasn't scratching like crazy all day. My hair looks fuller than I've ever seen it."
— Annette G., Verified Buyer · ★★★★★
Days 28+
92% of clinical trial participants reported fewer flakes and reduced scalp buildup, and their scalp feeling calmer and more soothed, after 4 weeks.*
Built By Someone Who Lived It, Not A Boardroom
Our co-founder spent a decade failing with prescriptions, steroids, natural remedies, and countless products that stripped his barrier without clearing the buildup underneath. So he built a formula that did the opposite: support the barrier, clear the buildup.
His scalp calmed down that same night. That formula became the Calming Seborrheic Serum.
More From Real Customers
"Always have struggled with these white flakes. I went to a dermatologist but this has been 1000 times better. Even my mom has noticed. I do a lot of sew-in and hair extensions. I use to be embarrassed asking people to take down my hair because of all the nasty flakes. But now, not a flake in sight!"
Erika M., Verified Buyer
"After diagnosis from my dermatologist and doing my own research, I stumbled across this and decided to give it a try 'just to see.' I finally have nothing under my nails when scratching at my scalp, for the first time in at least 5 years. I'm so happy to finally have relief!"
Ryan S., Verified Buyer
"It has been so great to not itch!!!! I saw a complete change in less than a month. No more flakes on my clothes either. I definitely will be ordering again."
Melisalyn M., Verified Buyer
How It Stacks Up
Swipe to compare
Dermazen Scalp Relief System
Medicated Shampoos & Prescriptions
Natural Oils & Home Remedies
Contact time
8+ hours (overnight serum)
~2 minutes, rinse-off
Varies — often left on
Skin barrier
Formulated to support it
Can strip it with repeated use
Can disrupt it (oleic acid)
The buildup layer
Clears it overnight
Not designed to reach it
Can make it worse
Face-safe formulas
Yes
Not typically formulated for the face
Sometimes — same barrier risk applies
Real guarantee
60-Day Peaceful Skin Guarantee
Rarely offered
None
Approach
Complete system — overnight, wash day, in-between
Single-step product
Usually single-step process
Swipe to compare
Clinically Studied.
In a 4-week clinical study, participants using the Calming Seborrheic Serum reported:
92%
Reduction in Flakiness*
92%
reduction in scalp buildup*
92%
said their scalp felt calmer and more soothed*
88%
reported improved overall scalp health*
76%
felt less self-conscious about their scalp*
Dermatologist-confirmed, based on evaluation of before-and-after photos:
77%
showed dermatologist-confirmed improvement in scalp health*
66%
showed dermatologist-confirmed improvement in flakiness*
Questions,
Answered
I've already tried prescriptions and medicated shampoos. How is this different?
Most prescriptions and medicated shampoos are designed to rinse off in about two minutes, and many can strip the scalp's protective barrier with repeated use. Our overnight serum stays on for 8+ hours and is formulated to support the barrier instead of stripping it, while targeting the buildup layer that most treatments were never designed to reach.
Can I use this alongside a prescription treatment or steroid cream from my dermatologist?
We always recommend checking with your dermatologist before combining treatments. Dermazen products are formulated without the harsh surfactants common in medicated shampoos, but your dermatologist knows your specific treatment plan best.
I've already tried natural oils and home remedies. Won't this be the same?
Not exactly. Many popular oils — coconut, argan, olive — contain a fatty acid that can disrupt the scalp's protective barrier and interfere with normal skin cell shedding, which can contribute to more buildup, not less. Our formulas are made without those oils.
How fast will I notice a difference?
In our 4-week clinical study, participants reported noticeable improvement as early as week one, with 92% reporting less flaking and buildup by week four.* Individual results vary, and consistency matters most.
What if it doesn't work for me?
You're covered by our 60-Day Peaceful Skin Guarantee. Try it for up to 60 days — if your skin isn't noticeably calmer, we'll give you a full refund.
Is this safe for face symptoms too?
Yes. Dermazen also serves customers dealing with flaking, redness, and irritation on the face, not just the scalp — see the Peaceful Skin System for a routine built for both.
60 Days Or It's Free.
Fewer Flakes. Calmer Scalp. Zero Guesswork.
Try the Complete System for 60 days. If your scalp isn't calmer, it's on us.
60 Days or It's Free** · Free US Shipping
- PPPaula P.Verified BuyerRated 5 out of 5 stars1 week agoGreat Product
I only needed to use this product a few times to see dramatic results. In a few weeks, it did what prescription products couldn't do in years.
- HBHarold B.Verified BuyerRated 5 out of 5 stars2 weeks agoWent too long trying other products… but only THIS gets it done for me.👍🏿
If you’ve got scalp irritation… DONT think about it, DONT wait, just BUY IT!! 🙌🏿
You’ll thank yourself later… Just remember, consistency is key. (Do the subscription)🙏🏿
- NKNiharika K.Verified BuyerRated 4 out of 5 stars2 weeks agoLove this product
This was my introduction to Dermazen. This product helped immensely when I first got it and continues to be excellent. I alternate with this serum and the moisturizer
- BDBrooke D.Verified BuyerRated 5 out of 5 stars2 weeks agoInstant soothing
Partnered with the smampoo this stuff is amazing. I put in on right before bed and it instantly soothes my scalp making sleep so much more pleasant. I tried many products before Dermazen with no success. It has been a life saver
- CWCatreena W.Verified BuyerRated 5 out of 5 stars2 weeks agoI use this EVERYWHERE
I put it on my scalp a few times a week and sometimes in combination with the scalp moisturizer. The absolute beauty of this one, I put it anywhere I see a dry patch. It clears it right up, sometime overnight and other times a couple of applications. It works miracles. I really wish I had taken before/after pictures of the area under my *******. It was really dry but now it's not. Makes me happy!
*In a 4-week open-label, single-group clinical consumer perception study conducted by Citruslabs (n=27 test subjects, 18 and over). Results based on participant self-report unless noted as dermatologist-confirmed. Individual results may vary.
**Try The Complete System for up to 60 days. If your skin isn't noticeably calmer, we'll give you a full refund.